To summarize, the two killer features for me are Web APIs and the built-in toolchain.
I understand the skepticism other Node devs have when faced with Deno. I have been using Node since 2010, and there is hardly anything I cannot do with it (or didn't do at one point), yet Deno makes a lot of these things much simpler. My last straw was trying to run Jest tests on TS code compiled into a Node.js ESM module. I believe I spent more time figuring out workarounds for a myriad of issues in Jest+ Node+TSC chain, than it took me to switch to Deno where all of it came out of the box.
[1] https://itnext.io/moving-libraries-to-deno-the-whys-and-hows...
edit: spelling