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Basically all Ryzen 5000 series chips can become compatible if your motherboard OEM releases an updated BIOS.

If your OEM really does provide an update to the BIOS to accomodate the 5000 then it sounds like a relatively good incremental upgrade path.

I currently have a 2600 paired with an X370 and have been meaning to try APUs and play around with passthroughs more with the RX580.

I was pleasantly surprised after I checked my Asus Prime X470-Pro driver page today, and noticed they released a BIOS update for 5800X3D!

Not to say for certain I plan to get it, but it's great that the support is there the day AMD announces it!