Besides being better suited to non-technical users (as joehewitt points out on this very thread), it also has an advantage of running in the background, i.e. you don't have to remember to run anything.

Also, there's this webapp called http://droppages.com/ which makes publishing from DropBox even easier.

Though personally, if I had to help a non-technical friend with setting up a blog, I'd just send him to Wordpress.com.