Not sure what you're talking about. They're are double-blind placebo clinical trials with injectible drugs all the time.
For orally dosed RCTs, often the pill making process is the way the blinding is done -- i.e. they're either in brightly-coloured gelcaps or a film or sugar coating. If it is a double-blind RCT it must be double blind. All of this will have been explicitly examined in the ethics statement for a trial and very, very prescriptively laid out.