I use them on my phone (which is the default and I didn't bother to change), but never get used to them on computer screens. I'm pretty sure if I give it more time I can quickly get used to, but just didn't see the appeal enough. I do have a yellow light in my room.
But then again I don't use dark mode either, so maybe I'm just a weirdo.
I also only use daylight bulbs in my house. "Soft white"/yellow bulbs give things a creepy feeling for me.
I wonder if the people that like f.lux are also the same people that claim that light themes are blinding, because I'm of the opinion that if you find a completely white screen is blinding, then either your brightness is too high or you don't have enough ambient light in the room.
In my experience it‘s sufficient to adjust the display brightness to roughly match the ambient lighting; no need for blue-light filtering.