1, which is very practical, is that it doesn't explain why the wave function always decoheres in the same way. In experiments, you can always chose the basis of measurement, and get some definite results in that particular basis, while the properties in another basis remain indefinite. But, in classical reality, all objects have definite properties in the same basis (say, positions in the same Cartesian coordinate system). This is known as the preferred basis problem, and decoherence can't explain it.
2, which is somewhat more philosophical, decoherence doesn't explain the quantitative relationship between the wave function and the probability of observing a particular outcome. Indeed, in MWI it's very hard to even define probability in a coherent way, since all outcomes actually happen and there is an uncountable (in the mathematical sense) number of outcomes.