"Shut up and calculate"
If "understanding the nature of reality" is your goal then engaging with various interpretations of QM is unavoidable.
(which is not to say it will be fruitful. This stuff might be genuinely beyond the reach of science. We might be hitting the brick wall of the unknowable. But that's not an excuse to stop trying. Some current formulations of the question are probably meaningless or based on false premises but philosophy, theoretical physics and experimental physics creep forward hand in hand)