The "manylinux" platform tag definition means GNU libc. musl libc systems are not within the "manylinux" Python platform, they are a separate "musllinux" platform tag.

See: PEP 600, PEP 656.

While the manylinux infrastructure project may use Alpine to produce "musllinux" binaries, Alpine will never be usable to produce "manylinux" binaries. So Alpine would only be useful in addition to another distro, not instead of another distro.

See: https://github.com/pypa/manylinux/pull/1135 .

Alpine is a supplement. It can't replace the others. It hasn't been widely accepted by the community yet. I believe many python projects are not afforded to replace libc.