It's not terrible to have one big struct, but sometimes it can inhibit the reuse of components in more than one system.

When you call a function that takes this struct as an argument, how do you know which members of the struct really need to be populated? Its dependencies aren't clearly documented. (They are over-specified. It's like a function with many unused arguments.)

If a subsystem only uses some members of the struct and you want to enforce that, maybe you pass in a smaller struct, or pass the struct members as separate arguments.

This is something you'll likely have to do if you want to extract a library for other people to use. Libraries are used in multiple systems, which might or might not have their own big struct.