Caloric restriction in humans reveals immunometabolic regulators of health span

If you’re noticing a large difference, it’s likely due to appetite related changes or even simply perception differences, not actual energy expenditure changes.

Secondly some foods increase inflammation, some reduce it, when inflammation occurs, you could compliment it with chemicals/supps that are needed for cell regeneration, things like choline will help here, which is a chemical found in the cell wall, or if you reduce inflammation with things like painkillers, then look at what the painkillers are doing ie P450 enzymes.

There's loads of chemical & biological pathways in the body and you need to map out what they all do. Studies like this are just a snapshot of part of process and ideally you would sometimes need two or three studies using chemicals at different amounts to get a better idea. Chemistry will also help give insights into the chemical pathways, like how fast a reaction might take, things like that.

> we're conditioned to feel hungry three times a day,

Ghrelin is like an alarm clock, to break that eat at random times of the day.

> compulsively, or out of sheer boredom. Stress, look at antioxidants, maybe a fruit juice and some stomp/jog/run around the block or down the street and back.

Probably the easiest way to get fit is little regular blasts of exercise, but you'll look like a fool to your neighbours. Little and often until fitness levels get up to something substantial. Some banks/city firms provided a gym at work for traders to go and have a quick 5-10min blast/exercise until exhaustion before returning to the desk to carry on, it could be weights, rowing machines and running machines, but its enough to release the pent up energy. This is why working from home or a small business could be harmful to your health. A good company with desk based work would lay on gym equipment, you need a minimum amount of exercise.

Starting from a high fitness level, a week dedicated to all waking hours doing a variety of exercises, saw my fitness levels substantially increased, like better than military PT instructor level.

Caveat. I'm not qualified in anything. JMO.

There are clearly somewhat distinct sensations that in my English-riddled mind all resolve to ‘hunger’. Then in my head i think ‘hmm, I’m hungry’ and so i do what i do when I’m ‘hungry’. I think this is what leads to me those curious moments where I’m standing in front of the refrigerator trying to remember how I got there.

I’ve recently started using ’snacky’ when i have that desire to crunch on something salty. As dumb as it sounds it has helped me ride it out vs mindlessly grabbing something from the pantry.

It's a vicious hormonal circle: https://en.wikipedia.org/wiki/Ghrelin

Your body gets acclimated and expects three meals a day (+snacks if that how you were raised), anyone who has a pet and feed him at regular interval knows how it works. At that point it doesn't matter if you're hungry or not, your body will signal that you _need_ food. Most people follow what their body tells them without any after thought and that's how we get 70%+ of overweight people in the west.

Once people see food as fuel they usually have a whole different view on the topic.

Cartilage wear and tear is the only thing that will really slow you down and put you on a spiral of being unable to exercise effectively and thus getting frailer. But maybe we will discover ways to regrow cartilage.

I’d say the fasting method is just another alternative for people to combat aging if they don’t feel like working out, but you can’t mix the two methods. Choose one path or the other.

But I am wondering my self too, what's the effect when you combine CR with exercise. 15% out of 2000 calories is 300 cal or about 30 mins jogging. So instead of eating less, will the effect be similar if I spend 300 cal more everyday through exercise?

Some think it's a myth. It makes sense if you think about it, the body uses a lot of energy and resources to build muscle (and tendons, and to mineralize bones) only to destroy it right away at the first intake dip, not even considering the primary source for energy storage, which is fat?

Caloric restriction burns A LOT of fat. It's why it's there in the first place.

https://www.dietdoctor.com/does-fasting-burn-muscle

The research seems to show that if you're trying to be muscular, CR is probably not going to help you. However, CR actually has some positive effects on exercise performance and outcomes for activities that don't revolve around raw strength. Unfortunately, there's very little research on CR vs. strength training in people who are not elderly and not overweight. I share your frustration there - so much of the hype around CR comes from it being an easy solution for people who are not already physically fit.

This is coming from someone who did tons of hard exercise from 16-26 then completely reworked my approach from intensity to volume, started restricting calories and reduced protein intake. That said fitness is a journey and you should always be willing to completely reverse everything you think you know.

https://www.juvlabs.com/your-health/healthy-aging-lifestyle/...

https://www.google.com/search?q=site%3Anews.ycombinator.com+...