> Is there any evidence that replacing a comma with a full stop makes a sentence easier to read
You can't generally make two grammatically-correct English sentences by starting with one and swapping a comma for a full stop, and if you can find a case where you can, it probably doesn't preserve meaning, even in the approximate (losing distinctions of how tightly coupled ideas are) sense you can with a semicolon rather than a comma.
But, generally, yes there is considerable evidence that shorter, simpler sentences (even if the total work is similar length) are easier to read, at the expense of reducing the space of ideas that can be clearly expressed.