Interestingly, this is how (surgical) sedatives usually work.
They increase the average activity of all neurons, so the brain is losing consciousness, because no coherent thoughts can circulate anymore.
They increase the average activity of all neurons, so the brain is losing consciousness, because no coherent thoughts can circulate anymore.
And ketamine, the most common pediatric and veterinary anesthetic, has a complex mechanism of action acting on GABA, NMDA, and other receptor systems, often with generally inhibitory characteristics [2] and with definite decrease in brain activity in animal models [3].
[0] https://www.ncbi.nlm.nih.gov/books/NBK430884/
[1] https://elifesciences.org/articles/60824#:~:text=The%20broad....
[2] https://journals.lww.com/anesthesia-analgesia/Fulltext/1998/...
[3] https://www.sciencedirect.com/science/article/abs/pii/002839...