HTTP/2 has indeed massively benefitted CDNs by providing more effective capacity per buck, but UDP based 3.0/QUIC will singlehandedly destroy it, and bring it to below HTTP 1.1.
Cloudflare: https://blog.cloudflare.com/http3-the-past-present-and-futur...
Akamai: https://developer.akamai.com/blog/2020/04/14/quick-introduct...
Fastly: https://www.fastly.com/blog/why-fastly-loves-quic-http3
Not to mention Google, which uses it a lot for regular pages and for content (eg: YouTube video).
Adoption client-side also seems to be moving quickly too. I looked at the stats for 2 of my sites and HTTP/3 is now at 60-70%, with HTTP/2 having dropped to 25-30% already.
Also, if this blog post from 2020 is correct, performance per buck isn't that bad with some teaks: https://www.fastly.com/blog/measuring-quic-vs-tcp-computatio...
I assume things have evolved since 2020.