Ask HN: How do AJAX-heavy, non-static-content sites offer ads?

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How do AJAX-heavy sites (where users spend the majority of their time on a single page) server ads? As far as I know, once a site is loaded, that ad will be staring at the user throughout his session. Is there an option (AdSense or ad other networks) that would display new ads every, say, 5 minutes?

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I haven't actually tackled this problem, but using setTimeout to reload would be my first attempt at this issue. If that doesn't work, I might design my app in such a way that it can remember its state, and make it so that some buttons actually refresh the page. (This would detract from user experience, but hey, Ads do the same)

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