Sometimes they're vibrant little untouched spots on the map - sometimes they're little dried up outposts of humanity, with some grand buildings left as testament that people once believed this place would prosper, and that there was money here at some point.
It's something I've always wondered at - you go out to rural america, there are a ton of small towns with really grand buildings in them, clear evidence that there was capital there at one point - and now its all gone - where and why did it go? The when is obvious usually, the other two, not as much. Thats an aside however.
I'll defend eating at the familiar when tired or worn out, but I do suggest trying the local color, you never know what you'll find out there - it might be good or bad, but it will almost certainly be memorable.