The 3D animated film Spider-Man: Into the Spider-Verse (2018) has a refreshing 3D/2D hybrid visual look that breaks away from the 3D aesthetic common across the industry. I suspect in the future we'll see more animated films with a 2D aesthetic but created with 3D software.
Aside: Disney produced lots of behind-the-scenes for their 2D animated films in the 50s and 60s. Here's one on the MultiPlane Camera - a camera setup that gave 2D animation greater depth:
Walt Disney's MultiPlane Camera (1957): https://www.youtube.com/watch?v=YdHTlUGN1zw