As somebody that experimented heavily with psychedelics when I was much younger, my opinion is that the 2C-B/E/I group have definite possible therapeutic value, and the main thing causing stagnation is the ridiculous hippy mindset that it’s ~synthetic~ and therefore bad. It’s ridiculous.
Over the past few years it’s been interesting watching polite society “discovering” psychedelics. I really can’t wait for these people to find the therapeutic value of smoked/IV DMT, especially considering that it’s WAY safer than ayahuasca.
I would love to see a study on the possible therapeutic value of dextromethorphan, but as far as I’ve seen it’s not really on the radar. I know it seems weird, but from subjective experience I found it to be very helpful a few times as a teenager. I used to jokingly call it “therapy in a bottle.” It’s a real shame that most DXM-containing products nowadays in the US come mixed with other compounds that make it dangerous to take at a recreational/therapeutic dose.