Is this only effective at small scale? Many of the biggest hedge funds in the world that do high frequency make money by effectively front-running the book. If you are executing these trades across exchanges I don't see how you don't get front-run by HF firms.
This is the same problem eth et al are dealing with in crypto swaps due to Miner Extracted Value (reordering the tx in the block to favor miners extracting value by front running trades).