I've had a few issues (NixOS, sway). Mainly screen capture. XWayland apps can record windows, but not my whole screen. Wayland apps can record my whole screen but not individual windows. I also don't know how to get XWayland to match my sway display resolution as it is only half the resolution.

Also libinput via sway doesn't have a way to disable the touchscreen if I'm using a stylus as far as I'm aware.

I'm sure there are solutions to some of these, but given I already spend a significant amount of time fiddling with my NixOS configuration I'm already quite an outlier with regards to the amount of effort I am willing to spend and even I'm exhausted.