If you are displaying images with one pixel lines, yes. Buy how often do you view an image scaled to exactly one image pixel per screen pixel. And when it comes to UI and font toolkits, they account for variable scaling aren't usually drawing single pixel features. Anyway I haven't noticed any blurring. You'll only really get noticable blurring if you render at say 1x and display at more than 1x because the detail just isn't there.