Otosclerosis. It causes conductive hearing loss, affects 10% of the population. Its essentially abnormal bone turnover inside the ear (Stapes) that becomes fixated leading to conductive hearing loss and eventually full deafness in some cases.

The current solution is to remove the diseased bone and fitting a prosthesis, it has risks and hearing doesn't always return to normal.

I always wondered why this can't be fixed using ear drops to administer Biophosphonates in the effected ear for a non invasive solution. In terms of 'lossening' an already fixated Stapes, why not a solution that is found to effectively dissolve the abnormal bone together with Biophosphonates.

It could be administered every so often to ensure minimal progression.