There are almost no big trailers delivering goods to Manhattan. It works well, just like it works well all over the world. It allows people to move around more quickly and safely. It works well even though Manhattan is ~1% of the US population and doesn't dominate economically to the extent of some world cities. It's certainly not "unsafe" (?!) for the residents of Manhattan (a direct quote). I don't know what "unpragmatic" means when applied to a system that works.
Banning big trucks from places where there isn't room and they get in the way is great. I hope they ban them in more places. I hope they ban anything bigger than a Transit van. I hope they transfer enforcement to a less corrupt, lazy, anti-city/pro-suburb agency than the NYPD. In short: big trucks in cities suck. I'm done.