It's a frame capture from a Doom 3 promotional trailer. In fact, I was the one who captured it and uploaded it to Wikipedia in 2004; it's nice that this article calls it a "classic shot" (that's what I thought too when I saw the scene in the video the first time). With all credit to the actual photographer, of course!

I imagine that's a photographic issue given that his untouched mouse is also a blur.

I'm pretty sure the blur is radiation interference from the monitor.