This destroys all your B-cells in your body, right? That means the B-cells aren't available for normal operation any more, right? I guess it's better to be immuno compromised than dead...
Gilead just reported a 5 year follow up on their therapy : https://www.gilead.com/news-and-press/press-room/press-relea... . " 92% of Patients Alive at Five Years Have Needed No Additional Cancer Treatments; Data Suggestive of a Potential Cure for These Patients "
Having a working immune system won't do you any good if you're dead
CAR-Ts are now being tested in much earlier lines of therapy.
If you have DLBCL/FL, all treatments go after B-cells. CAR-T is just better at doing that and nothing else.