2FA is a good option for securing your centralized accounts. But unfortunately, if you're logged in on your phone and your phone is hacked, well, it's still game over.

For crypto currencies it may help to store them on a hardware wallet, since accessing your money will require explicit interaction. But, as far as I understand (please correct me, not up to date with the security mechanisms of hardware wallets), if your computer is compromised while doing it, you can still lose it.