If you use proper apostrophes instead of ASCII apostrophe / single quote, you don’t have to escape anything and you get better typography. "don’t" is easier to read than both.

If you’re on a Mac, Option-Shift-] will type it.

When you’re embedding SQL in a string, a you use ‘ a lot more than “. Not the only use case, but one to give some consideration.

Black will use single quotes if your string contains double quotes and no single quotes. It'll reformat

     print("\"Hello\" he said")

to

     print('"Hello" he said')

I think pretty much all formatters for languages that let you use either quote do this. It makes sense.

And 'do not' is easier to read than both :)