Spicy take :) Although building for a dynamic CDN (I'm thinking Varnish here) feels like building inside-out, I can't see a way to deliver pageviews as efficiently (in terms of CPU or Watts per view) without using a CDN and a lot of caching.
With Fly I guess you flip the architecture around and run code but cache a lot of partials that you assemble together. Nicer than working with ESI and its "cache it all but punch holes in the page and render those bits again" approach, but does the efficiency hold up?
My architectural misfeature would be ESI [1,2]. So useful and so painful to use. And that's before we get to varying support in different proxies and caches...
1. https://www.mnot.net/blog/2011/10/21/why_esi_is_still_import...
2. https://twitter.com/peterbowyer/status/1366324396026118149