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There's a sugar that most animals produce but humans don't[0]. These pigs have been genetically modified to not produce that sugar, the thought being that that's what's responsible for the xenotransplantation rejections[1].

[0] https://www.cdc.gov/ticks/alpha-gal/index.html [1] https://www.healio.com/news/primary-care/20201214/fda-oks-ge...

Doctor: "Now, most hearts couldn't withstand this voltage ... but I'm fairly certain your heart..."

Pig: "What was noise?"

Doctor: "The sound of progress, my friend."

This video is a good overview of the whole thing https://www.youtube.com/watch?v=0d8svvqX1c0

It is also becoming more common in drug research. It is fairly common to adapt animal genomes to be closer to that of humans so that the drugs will work in similar ways.