Chrome scripts require careful security analysis, just like software that runs with root privileges.
Firefox ships with zillions of lines of chrome script, and none of those zillions of lines "downgrade" any security features. Software isn't automatically secure simply because it came from Mozilla. Microsoft tried the same nonsense to scare people out of using Linux at one point... you'd have to be nuts to run kernel code that didn't come from Redmond!
https://searchfox.org/mozilla-central/source/dom/security/ns...
Those are useful mitigations, but disabling them for some custom user-chrome is unlikely to have a meaningful impact on your browser's security.
[0] https://searchfox.org/mozilla-central/source/dom/security/ns...
[1] https://searchfox.org/mozilla-central/source/dom/security/ns...
[2]: https://blog.mozilla.org/attack-and-defense/2020/06/10/under...
https://github.com/mozilla/policy-templates
It's from Mozilla.