Deny all.

In Safari I've unchecked "allow websites to ask for permission to send notifications" but it doesn't work - I still get banner ads in the page asking me for @#$@#$ notifications. No, just no. And don't try to evade the browser preference.

Law of "Not our popups": For every browser feature designed to improve the user experience, web designers will think that users could never (ever!) want it to apply to their site so they will do their best to break the feature and deliver the unwanted content or feature (pop-up windows, tracking/unblockable cookies, auto-playing video, etc..) in direct contravention of user preference settings.