The second is the inspect module that builds on that, allowing you to get the stack frames, inspect function signatures etc.
The third is trackbacks, which need the stack and themselves are introspectable.
The fourth is metaclasses (making dynamic classes at runtime).
These are heavily used in Python, and are optimisation barriers. For example PyPy (Python with a JIT) disables optimisations when “inspect” is imported or used anywhere in the call stack.
(that said, I guess the fourth one (metaclasses) isn't a clear yes/no, since OO is very different in js)
metaclasses isn't really a major optimization hazard, it effectively boils down to hijacking the "class" syntax to instead run some custom code. It's used by things like dataclasses and the Django ORM to use class syntax to make a little DSL.
None of those are insurmountable, they merely make writing a JIT harder if you want to support them: it’s hard to inline a function call if the inclining can have a visible effect.
All of them just as dynamic, if not more.
I’d say the lack of control flow structures and message passing would make it far, far easier to JIT.