I know you're probably not looking for a SaaS based on your message, however, I recently migrated from ProtonMail to mailbox.org because of reasons, and I really think it is worth using over self-hosted solutions.
A big reason for not going with self-hosted setup is because of the exact reason you mentioned. I just wasn't in the mood to manage everything myself and keeping my IPs in good standing. On top of that, the only place I could host it is on some cloud (I live in a small apartment in London, so self-hosting isn't very feasible), or worse, some smaller provider that potentially has low to no accountability. I felt like I'm just moving the trust from an email provider (who can arguably do a better job than I can) to a cloud hosting provider.
For me, mailbox.org has been great, better than PM. I got the standard package, which is €3 per month. It allows me to use both of my email domains (using a catch-all), and allows me to send emails from any sender (combined with Thunderbird's customisable send field, it's great!). It has full integration with any email client, as opposed to PM which requires either their app, or ProtonMail Bridge.
The initial set up was a bit weird, and definitely not as refined as ProtonMail's but in the end it worked. I'm able to use one of my domains as a 1 email per website, and the other for professional communications. They've also got an option to encrypt all your email using a PGP key, which you can combine with Thunderbird's PGP integration, or MailVelope.