For sure. Some people are ok with doing arbitrary tasks for the powerful as long as the money is good. Others of us, me included, care about actual impact on users and the world.
I remember interviewing one very sharp engineer who was desperate to get out of Facebook. He had been attracted by the exciting problems, but after a few years he was entirely sick of spending most of his time trying to shift metrics by fractions of a percent. Metrics whose only real meaning was, at best, increasing the money flowing into Facebook. And all of that was years before the recent revelations on the dangers FB poses and how little they care about that.
My current solution to this problem has been to work for an effective not-for-profit. It still has its problems, but my colleagues at least care about actual impact, and I'm still excited for the chance to make a dent in problems I care about.
(As an aside, I'll note that it's also possible to find meaning in commercial work. I love building things for users, and I'm happy to charge for them when we're creating real value. But given American managerial culture, user benefit is often at best a side effect at many companies.)