I'm aware of a couple more forums where people tried ISRIB and still claim to have lasting problems from it. One group was led by professional chemists who seemed like they knew what they were doing when it comes to testing and validating the product was pure.
It's amazing what people can access now, but self-experimentation with these compounds is a terrible idea.
Eventually learned it was a blood disorder and a simple blood thinner was the answer.
You might like the #1 book on Amazon under cardiology currently. Its thesis is cholesterol has nothing to do with heart diseases, its all in the clots. Good detail of the clotting process and relatively understandable.
Every time I try and go off them all the symptoms come back. So it was this that micro-clots was determined.
Also when drawing blood nurses kept complaining that my blood clots to fast.
I think it depends what the alternative is. If you have something like Alzheimer’s and no other alternatives, maybe self-experimentation is not such a bad idea.
(For anyone unaware, it's a bunch of neuropeptides harvested from pig brains that you typically either inject or - fittingly, due to the source - snort directly into your brain through your nose.)