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Comment by forgotmyoldacc | Hacker News Reader

No surprise, there's already a subreddit dedicated to people trying out this experimental molecule: https://reddit.com/r/isrib

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It's pretty shocking to me people are so willing to experiment on themselves with some research chemical that has mostly studied in mice.

Desperate people will do whatever they can to improve themselves. Imagine you have neurogenerative disease and in few years you will be stuck to wheelchair forever.

Eh, people have different risk appetites and not everybody wants to wait for an authority figure to say something is safe (especially when that authority figure is always slow, sometimes makes mistakes, and sometimes makes decisions based on politics). I don't fault people with a little self-experimentation as long as they're given the opportunity to understand the risks and rewards they're facing.

Maybe they're in particularly desperate situations? I do concur if these people are healthy/young though, seems insane to take something with side effects this concerning that don't even need proper trials to manifest if you're not working to fix a preexisting problem that hurts your lifespan/quality though.

I'd rather die than have a late stage neurogenerative disease. Plenty of desperate people.

Not even research chemicals my Dad had IPF and from what I could find Metformin was a promising off-label cure. But there was no way to try it. People get desperate sometimes not even the people who are sick but their caregivers.

My dad passed away April 21, 2021 on my birthday.

Sorry for your loss. Did you or your dad tried talking to doctors for a prescription? Metformin is a very common drug and has a safe profile, some doctors would be able to prescribe it off-label.

Thank you. And yes I even printed off some peer-reviewed studies about IPF and Metformin for Dad to take with him to the doctor. The doctor would "look into it" but I suspect that Dad who was not great at anything technical would have agreed with the doctor and not challenged him.

My mother has type 2 diabetes so Metformin was right there in the house. It's infuriating to think Metformin could have made Dad's life better. Maybe not cure him but at least help a tiny bit.

The other problem severely ill people who have been sick for years give up before they even know it. I saw it in Dad but I couldn't see the effects of anxiety which was also there until it was too late. Anxiety is what eventually killed him more than his disease.

You should probably link to https://old.reddit.com/r/isrib instead, which doesn’t block mobile users that don’t use the official app.

Sharing this slows down the web 0.0 movement reddit, twitter, and instagram are pioneering.

The World Wide Dots, rather than web.

Isn't it Web 1.5-ish? E.g., we have browsers but devs aren't satisfied with them as app platforms, so they use various techniques (in “original” web 1.5, applets or plugins or downloading a file that would be opened by a native app) to use web links to trigger running an app in a native, or at least more-to-the-devs-liking, environment rather than using web-native tech?

I assumed they just want notifcation permissions to spam people that don't know how to turn it off, so they can hijack their attention, and location permissions to make their ads more valuable through spying.

That and your contact list, phone call history, sms history, etc. Gotta build that relationship tree!

I use Sync on Android. You can make reddit links open there by long pressing on the app icon and making sure the links are setup to open there. https://imgur.com/a/4qKCgSB

You may already know this but on iOS at least: Apollo with the “Open with Apollo” extension will redirect “new” Reddit links from Safari to Apollo.

I dislike using apps when a web browser would do but Apollo is one of the great ones.

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