Oh-ho, no, not in my experience.
I used to be devastatingly introverted. Alcohol helped, but it’s nothing compared to GHB or MDMA. Ecstasy will give you the gift of gab like you can’t believe.
minor edit: I should say I am ignoring the context of where it’s acceptable to do such things. You probably shouldn’t do G at Christmas with the in-laws. (Though our quarantine Christmas this year with friends…) I’m just making a bit of a pedantic bit that there are club drugs out there that are pretty wild in how they can open you up socially.