Asian cultures are aware.

In China for example, tofu is one of the cheapest possible protein sources (think in terms of a massive pallet of it sold for five dollars) but people are generally aware that it is poisonous in some weird ways that won't kill you. Males are generally urged not to consume it.

This could be a knowledge of just the upper class, though. An unspoken suggestion to leave the tofu and soy for the poor.