I think neck strain was a bit of an issue at the beginning, but not any more. Aftermarket prescription lense adapters are critical if you wear glasses. With those, there isn't much eye strain. Not more than staring at a computer all day would cause anyway. Also an upgraded strap. I use the Oculus Elite strap, but I think there are plenty of cheaper and probably better third party options.
For coffee/water I use a closed tumbler with a metal straw and I just reach carefully. Double tap the side of the quest for pass through if you get lost.
The Discord is full of requests for solutions for seeing the keyboard. It has a pretty impressive virtual overlay for the keyboard, but IMO that is an unnecessary handicap. Instead of demanding a skeuomorph, it's much more pleasant to really learn to touch type. It took me about a week to get flawless. I'm even pretty good at the function keys since I started debugging in Vim.