It's among the best quality animation I've seen. Story is excellent in the beginning, though degrades to only decent towards the end as the video-game origins start showing through. Definitely worth watching, IMO.

(I also have no knowledge or interest in LoL.)

The ideas aren't anything new but the execution is pretty good. Overall, a solid 8/10 I think.

If you enjoy animated shows, you don't need to enjoy league.

I've never played league and don't like most anime, just found the show and thought it was amazing.