To a large degree, sedentary is sedentary, no matter how you dress it up. Our bodies did not evolve to sit (or stand) in a fixed location for most of the waking day. And our brain's health is highly correlated with cardiovascular health.
-The Atkins diet has some serious flaws (in short: not enough vegetables, not enough warning against harmful fats/oils/processing) but deserves real credit for the ongoing movement away from processed carbohydrates. He exposed the fallacy of associating dietary fat with body fat. He probably had more right than the 80's and 90's health establishment (that food pyramid was an abomination).
-The modern white-collar workplace is an absolutely bizarre environment for a species that's been without anything resembling a "building" for something like %99 of its history, let alone artificial light, computing metaphors or office chairs - experimentation with ergonomics and the whole enterprise of spending our waking hours indoors should be encouraged, not treated dismissively.
Stress management and reduction also comes to mind (of course taking a small break and moving around can help that).
I'm sorry I don't have a citation (nor am I going to dig for one) but this has been mentioned ad nauseam in prior threads. You should check those out (as well as the studies they discuss).