I think this is useless fluff. It’s essentially just a few compiler flags being changed. I’m pretty sure the Chromium engineers are very well aware of those and made the decision to use the one they did. I don’t know which ones, but opting for higher optimization has to have detrimental side effects.
Also, the lighthouse score changing?? Isn’t the entire point of Lighthouse to grade the website and not the machine the test is being run on???