Would be interesting to run these tests on different groups experiencing varying degrees of gravity, on a spinning station perhaps, and see what's the minimum amount of gravity we can get away with while keeping side-effects to a minimum.
Long term tests would also be very valuable, 1-2 years.
You could imagine a system where you 'space elevator' objects and people via the connecting cabling, whilst pumping fluid to offset the mass. You would likely want each side to be manned by two people.
You could later add more modules if designed correctly too. They would likely approach and attach to the centre (in a pair, one either sude), match the spin and then slot into their respective 'slots' and rotate on an arm.
Otherwise the difference in gravity acting on different sides of the body and more importantly the Coriolis forces would wreak havoc and cause more harm than good.
Everything in chemistry is equilibrium-driven, so I can readily see some process evolving with the assumption of X units of some chemical flowing through this system, and trying to restore homeostasis in space by increasing hemolysis.
I was imagining intracellular processes being effected. There are such processes in plants that are usually used for steering. In animals cells, if such thing exists, it may be minor efficiency changes in processes that add up to diverging from homeostasis.