As your article mentions, decarboxylation is a required step for cannabis extracts to have any psychoactive effects. So, presumably commercially marketed edibles are decarboxylated.
It's my understanding that raw marijuana contains both psychoactive cannabinoids as well as precursors which require decarboxylation.
If that's the case, I am not sure that decarboxylation is _required_ - however it is recommended as it increases the _amount_ of bioavailable cannabinoids (i.e. best bang for your buck.)
Only THC binds very well to the CB1 receptor. THCA does not bind well to either receptor.
Cannabinoids that bind to CB2 receptors in the immune and gastrointestinal systems affect inflammatory and immune responses.
Edit: added compound names