Window.js is a subset; it doesn't include the DOM nor the CSS APIs, nor a lot of web APIs.
Window.js is a tool I wish I had for exploratory 2D (and 3D) programming, without having to install multiple tools, SDKs and runtimes, and without the restrictions that web pages have when it comes to desktop applications. I wanted something like Processing but with more control, or like <canvas> but without all the browser cruft around it, and in a native window.
I think it could be a very useful tool to learn WebGL via webglfundamental.org, for example, and having something that runs on the desktop quickly.
A goal of Window.js is to eventually run Processing (p5.js), Pixi.js, Phaser and Threejs programs, as long as they don't use the DOM too much.