It would rock to have native GUI. Also, if I could know how to draw graphics... That would be very nice also, because having an interactive environment for graphics is the most awesome stuff that Pharo can offer (me).
For 2D graphics, Pharo uses Cairo binding named Athens (and Roassal as another convinient layer above that).
For 3D, you may be interesting in Godotalk (https://www.youtube.com/watch?v=ncmERef0EFo, https://pharoweekly.wordpress.com/2021/02/03/godotalk/)
There's also native pharo smalltalk stuff like athens, woden, and maybe others... Personally I have moved to using Dolphin Smalltalk and raylib bindings there as it's been more performant and I prefer Dolphin over pharo. Dolphin also has good external interfacing support and is more of a native Windows OS smalltalk distro. If you're looking for building native windows looking applications on windows at least probably your best bet is dolphin and it's free and open source.