That's not to say that cables or ropes cannot fail, but when they do so, failure of many individual components is required.
A recent example is the failure of support cables for the Arecibo radio observatory in Puerto Rico in 2020. This was the result of a progressive failure played out over months, though at an accelerating rate, until the final catastrophic failure and loss of the instrument as a whole. (This wasn't wholly unforseen and was precipitated by a long period of rather intentional neglect of maintenance.)
Even after the failure of two complete cables, the remaining cables supported the load of Arecibo's instrument platform. On 1 December 2020, strands of one of the remaining cables began breaking, at an accelerating rate, leading to the total failure of that cable, then a second and third, and with it loss of the instrument platform. The final moments were captured on video.
Sequence begins at about 55s here: https://yewtu.be/watch?v=b3AASKr_iHc
So long as the chain is not loaded near its tensile limit, then the grain boundaries that support the load within each link do so in parallel and are therefore redundant.
The selection of the allegory of the chain was intentional -- each link must be properly formed, or the entire chain will fail. If it breaks, it is surely correct to say, "the chain broke", but in truth, it was actually link-86.
For JWST, the remarkable/audacious thing is that many links in the chain from launch to observation are potential single-point failures. Furthermore, many of them haven't ever been tested independently in space... ever. It is a hell of a triumph that JWST has gotten this far already.
If even a small fraction of the instrumentation works at this point, we are going to learn a ton about the universe, simply due to JWST's position, collecting-area, and mirror-diameter.
Also, I don't want to underplay JWST's success or its challenges. But, when saying 300+ SPOF conditions, one has to specify at what abstraction level. Otherwise, it can be misleading.
Single point of failure doesn’t mean “weakest link”. It means if this one piece (“single point”) fails, the whole system will fail.
Contrast a second chain, or double linked chain, so if any link fails the load is not lost.
If you know the strength of every link in the chain with perfect accuracy, and you know that the only potential cause of failure is too much weight being placed on the chain, then the only link that can fail is the weakest[1] one because no other failure can happen before that one.
But really you need to design for the idea that various things might happen. Someone else gave the example of a person choosing a link to cut with bolt cutters. The person's choice is what's not predictable in that example.
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[1] And if you assume it's not possible to have two links that are exactly as strong as each other.
Which isn't relevant since (obviously) no one was talking about how many links are the weakest link.
"it is at that link where the chain will break"
Wars have been lost by thinking this way. e.g., D-Day was a successful assault on a strong link.