Yes, I am aware of Acme and Sam and I am aware that good mouse driven interfaces are faster than using keyboard driven interfaces.
I should point out that mouse driven interfaces are only better than keyboard driven interfaces when designed competently to actually take advantage of mice (e.g. acme). Text editors such as VSCode suck in comparison in terms of their mouse usage, the way Acme uses mice is worlds different from the extremely boring and inefficient use of mice that VSCode has.
That aside, the question is not if utilising a mouse well makes for a faster interface than restricting the interface to only using the keyboard. The question is if multiple-cursors are a good use of the mouse.
I'm sure there's some situations where multiple cursors are faster than using editor commands, but the point I was making is that in general I've found multiple-cursors to just be a distraction which slows me down. This might be because I don't work from a desktop and use a trackpoint, or maybe because when I do use a desktop I use a trackball. But from what I actually remember, most of my time with multiple-cursors has been spent trying to reason about how applying a certain input in 5 different places will affect the text, and then undoing mistakes. I have found the regular expressions that vim has as well as the structural regular expressions in Sam and Acme to be far better at describing operations which need to occur in multiple places.
Please do look into vim's regular expressions, there's a surprising amount of stuff that they can do which most people are not aware of.