- how long the immunity gained from having recovered from Omicron lasts
- how well that immunity protects against other current (and future) variants of covid
- what kind of new strains of covid appears in next several months / years that may replace Omicron
- how many people we are able to get vaccinated globally
- advances in new and better vaccines becoming available (complete with antiviral pills etc)
And probably quite a few other factors that weren't on top of my layman head...