My question was what percentage of results in mice generalize to humans?
To confirm I'm interpreting your answer directly. It depends on how the scientists use the tool. It is good at verifying certain aspects but not others.
Accuracy is very high when you are studying a metabolic pathway that is (near)identical in humans and in mice.
>To confirm I'm interpreting your answer directly. It depends on how the scientists use the tool. It is good at verifying certain aspects but not others.
Yes. More precisely: animal models are accurate when the metabolic machinery in humans is also found in the animal model.