Sometimes I feel like the only one who likes new twitter.
I would like middle-click-to-open-in-new-tab to work more consistently as well.
Frankly, I don't use Twitter enough to be affected by their UI in general, but I strongly dislike the URL hacks. I think websites should stick to real URLs, and only use Javascript page changes if the new History methods are available.
Thing is, if you got a new/fast computer, you don't notice this, and then yeah, the new interface is just fine.
Except that, for the functionality it provides, there's not really a good excuse for the page to be so slow.
It's particularly bad whenever you try to go through a long list of people you are following and try to unfollow lots of them. Takes an age to respond to clicking the unfollow button.